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Article

Gene and miRNA expression profiles in PBMCs from patients with severe and mild emphysema and PiZZ alpha1-antitrypsin deficiency.

International journal of chronic obstructive pulmonary disease - 1 Jan 2017

Esquinas Cristina, Janciauskiene Sabina, Gonzalo Ricardo, Mas de Xaxars Gemma, Olejnicka Beata, Belmonte Irene, Barrecheguren Miriam, Rodriguez Esther, Nuñez Alexa, Rodriguez-Frias Francisco, Miravitlles Marc

Abstract excerpt

INTRODUCTION: COPD has complex etiologies involving both genetic and environmental determinants. Among genetic determinants, the most recognized is a severe PiZZ (Glu342Lys) inherited alpha1-antitrypsin deficiency (AATD). Nonetheless, AATD patients present a heterogeneous clinical evolution, which has not been completely explained by sociodemographic or clinical factors. Here we performed the gene expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29238183
DOI: 10.2147/COPD.S145445
PMCID: PMC5713702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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