Article
NKX2-1 expression as a prognostic marker in early-stage non-small-cell lung cancer.
BMC pulmonary medicine - 13 Dec 2017
Moisés Jorge, Navarro Alfons, Santasusagna Sandra, Viñolas Nuria, Molins Laureano, Ramirez José, Osorio Jeisson, Saco Adela, Castellano Joan Josep, Muñoz Carmen, Morales Sara, Monzó Mariano, Marrades Ramón María
Abstract excerpt
BACKGROUND: NKX2-1, a key molecule in lung development, is highly expressed in non-small cell lung cancer (NSCLC), particularly in lung adenocarcinoma (ADK), where it is a diagnostic marker. Studies of the prognostic role of NKX2-1 in NSCLC have reported contradictory findings. Two microRNAs (miRNAs) have been associated with NKX2-1: miR-365, which targets NKX2-1; and miR-33a, which is downstream of NKX2-1. We...
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