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Article

Expression of Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) predicts poor prognosis in lung adenocarcinoma and EGFR-mutated adenocarcinoma patients.

QJM : monthly journal of the Association of Physicians - 1 Apr 2016

Sun Ping-Li, Jin Yan, Park Soo Young, Kim Hyojin, Park Eunhyang, Jheon Sanghoon, Kim Kwhanmien, Lee Choon-Taek, Chung Jin-Haeng

Abstract excerpt

BACKGROUND: Sodium-potassium-chloride cotransporter isoform 1 (NKCC1) is an active ions cotransporter and modulates cellular volume and migration. NKCC1 blockers can inhibit cancer cell growth. AIM: We aimed to elucidate the expression and prognostic significance of NKCC1 in non-small cell lung cancer (NSCLC). METHODS: We retrospectively analyzed 788 NSCLC patients with either adenocarcinoma (n = 503) or squamous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26559081
DOI: 10.1093/qjmed/hcv207

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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