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Novel Mutation in Cytochrome B of Plasmodium falciparum in One of Two Atovaquone-Proguanil Treatment Failures in Travelers Returning From Same Site in Nigeria

1 Jan 2014

Abstract excerpt

BACKGROUND: Atovaquone-proguanil (AP) is the most commonly used treatment for uncomplicated Plasmodium falciparum malaria in the United States. Apparent AP treatment failures were reported 7 months apart in 2 American travelers who stayed in the same compound for foreign workers in Rivers State, Nigeria. METHODS: We analyzed pretreatment (day 0) and day of failure samples from both travelers for mutations in the...

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PMID: 25734129
DOI: 10.1093/ofid/ofu059

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