Nanorate sequencing reveals the Arabidopsis somatic mutation landscape.

Abstract excerpt

The rate and spectrum of somatic mutations can diverge from that of germline mutations. This is because somatic tissues experience different mutagenic processes than germline tissues. Here, we use nanorate sequencing (NanoSeq) to identify somatic mutations in Arabidopsis shoots with high sensitivity. We report a somatic mutation rate of 3.6 × 10-8 mutations/bp, ~2 to 7× measured germline mutation rates. Somatic...

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