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Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis

11 Dec 2017

Abstract excerpt

The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation. Using a chemically defined human pluripotent stem-cell-derived cardiomyocyte differentiation system, we found that high glucose inhibits the maturation of cardiomyocytes at genetic,...

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PMID: 29231167
DOI: 10.7554/elife.29330

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