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Article

SUV420H2 is an epigenetic regulator of epithelial/mesenchymal states in pancreatic cancer

11 Dec 2017

Abstract excerpt

Epithelial-to-mesenchymal transition is implicated in metastasis, where carcinoma cells lose sessile epithelial traits and acquire mesenchymal migratory potential. The mesenchymal state is also associated with cancer stem cells and resistance to chemotherapy. It might therefore be therapeutically beneficial to promote epithelial identity in cancer. Because large-scale cell identity shifts are often orchestrated...

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PMID: 29229751
DOI: 10.1083/jcb.201705031

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