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Article

Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.

Nature communications - 1 Jan 2012

Sato Atsushi, Kasai Shinya, Kobayashi Toshiyuki, Takamatsu Yukio, Hino Okio, Ikeda Kazutaka, Mizuguchi Masashi

Abstract excerpt

Impairment of reciprocal social interaction is a core symptom of autism spectrum disorder. Genetic disorders frequently accompany autism spectrum disorder, such as tuberous sclerosis complex caused by haploinsufficiency of the TSC1 and TSC2 genes. Accumulating evidence implicates a relationship between autism spectrum disorder and signal transduction that involves tuberous sclerosis complex 1, tuberous sclerosis...

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Source

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Identifiers

PMID: 23250422
DOI: 10.1038/ncomms2295
PMCID: PMC3535343

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Rapamycin reverses impaired social interaction in mouse models of tuberous sclerosis complex.PMID 23250422Read ↗

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