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Article

Influenza A Virus Reassortment Is Limited by Anatomical Compartmentalization following Coinfection via Distinct Routes.

Journal of virology - 1 Mar 2018

Richard Mathilde, Herfst Sander, Tao Hui, Jacobs Nathan T, Lowen Anice C

Abstract excerpt

Exchange of gene segments through reassortment is a major feature of influenza A virus evolution and frequently contributes to the emergence of novel epidemic, pandemic, and zoonotic strains. It has long been evident that viral diversification through reassortment is constrained by genetic incompatibility between divergent parental viruses. In contrast, the role of virus-extrinsic factors in determining the...

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Identifiers

PMID: 29212934
DOI: 10.1128/JVI.02063-17
PMCID: PMC5809721

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