Article
Reassortment between avian H5N1 and human H3N2 influenza viruses in ferrets: a public health risk assessment.
Journal of virology - 1 Aug 2009
Jackson Sara, Van Hoeven Neal, Chen Li-Mei, Maines Taronna R, Cox Nancy J, Katz Jacqueline M, Donis Ruben O
Abstract excerpt
This study investigated whether transmissible H5 subtype human-avian reassortant viruses could be generated in vivo. To this end, ferrets were coinfected with recent avian H5N1 (A/Thailand/16/04) and human H3N2 (A/Wyoming/3/03) viruses. Genotype analyses of plaque-purified viruses from nasal secretions of coinfected ferrets revealed that approximately 9% of recovered viruses contained genes from both progenitor...
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