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Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death

29 Nov 2017

Abstract excerpt

The risk of emerging pandemic influenza A viruses (IAVs) that approach the devastating 1918 strain motivates finding strain-specific host-pathogen mechanisms. During infection, dendritic cells (DC) mature into antigen-presenting cells that activate T cells, linking innate to adaptive immunity. DC infection with seasonal IAVs, but not with the 1918 and 2009 pandemic strains, induces global RNA degradation. Here,...

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PMID: 29203926
DOI: 10.1038/s41467-017-02035-9

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