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Article

Disruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant.

Nature - 15 May 2014

Bonawitz Nicholas D, Kim Jeong Im, Tobimatsu Yuki, Ciesielski Peter N, Anderson Nickolas A, Ximenes Eduardo, Maeda Junko, Ralph John, Donohoe Bryon S, Ladisch Michael, Chapple Clint

Abstract excerpt

Lignin is a phenylpropanoid-derived heteropolymer important for the strength and rigidity of the plant secondary cell wall. Genetic disruption of lignin biosynthesis has been proposed as a means to improve forage and bioenergy crops, but frequently results in stunted growth and developmental abno...

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Identifiers

PMID: 24670657
DOI: 10.1038/nature13084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24670657-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Disruption of Mediator rescues the stunted growth of a lignin-deficient Arabidopsis mutant.PMID 24670657Read ↗

Mediator Complex Subunits MED2, MED5, MED16, and MED23 Genetically Interact in the Regulation of Phenylpropanoid Biosynthesis.Semantic proximity Read ↗

REF4 and RFR1, subunits of the transcriptional coregulatory complex mediator, are required for phenylpropanoid homeostasis in Arabidopsis.Semantic proximity Read ↗

Loss of FERULATE 5-HYDROXYLASE Leads to Mediator-Dependent Inhibition of Soluble Phenylpropanoid Biosynthesis in Arabidopsis.Semantic proximity Read ↗

Functional metabolomics as a tool to analyze Mediator function and structure in plants.Semantic proximity Read ↗

Transcriptome Analysis of Four Arabidopsis thaliana Mediator Tail Mutants Reveals Overlapping and Unique Functions in Gene Regulation.Semantic proximity Read ↗

The MED7 subunit paralogs of Mediator function redundantly in development of etiolated seedlings in Arabidopsis.Semantic proximity Read ↗

Pinoresinol rescues developmental phenotypes of Arabidopsis phenylpropanoid mutants overexpressing FERULATE 5-HYDROXYLASE.Semantic proximity Read ↗

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Chemically induced conditional rescue of the reduced epidermal fluorescence8 mutant of Arabidopsis reveals rapid restoration of growth and selective turnover of secondary metabolite pools.Semantic proximity Read ↗

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Natural alleles of Mediator subunit genes modulate plant height in chickpea.Semantic proximity Read ↗

Changes in secondary metabolism and deposition of an unusual lignin in the ref8 mutant of Arabidopsis.Semantic proximity Read ↗

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