Article
Exploring the biological basis of haemophilic joint disease: experimental studies.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 May 2012
Valentino L A, Hakobyan N, Enockson C, Simpson M L, Kakodkar N C, Cong L, Song X
Abstract excerpt
Haemophilia has been recognized as the most severe among the inherited disorders of blood coagulation since the beginning of the first millennium. Joint damage is the hallmark of the disease. Despite its frequency and severity, the pathobiology of blood-induced joint disease remains obscure. Although bleeding into the joint is the ultimate provocation, the stimulus within the blood inciting the process and the...
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