Article

Hypomethylation of The Low-density Lipoprotein Receptor Class A Domain Containing 4 Gene in Rheumatoid Arthritis in a Chinese population

2024-05-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Rheumatoid arthritis, a chronic inflammatory disease, is characterized by destruction of synovial joints. The pathogenesis of RA is unclear, and DNA methylation plays important roles in the expression of related genes. LDLRAD4 is identified from three GWAS, in which the expression of LDLRAD4 was different in RA. LDLRAD4functions as a negative regulator of TGF-β...

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Literature Corpus work: 1a0a2548-6be6-51d8-b759-d325c6599503
DOI: 10.21203/rs.3.rs-4318121/v1

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