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Article

Exome sequencing reveals mutant genes with low penetrance involved in MEN2A-associated tumorigenesis.

Endocrine-related cancer - 1 Feb 2015

Cai Jie, Li Lin, Ye Lei, Jiang Xiaohua, Shen Liyun, Gao Zhibo, Fang Weiyuan, Huang Fengjiao, Su Tingwei, Zhou Yulin, Wang Weiqing, Ning Guang

Abstract excerpt

Activating rearranged during transfection (RET) mutations function as the initiating causative mutation for multiple endocrine neoplasia type 2A (MEN2A). However, no conclusive findings regarding the non-RET genetic events have been reported. This is the first study, to our knowledge, examining genomic alterations in matched MEN2A-associated tumors. We performed exome sequencing and SNP array analysis of matched...

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Source

Identifiers

PMID: 25404689
DOI: 10.1530/ERC-14-0225

Genes

RET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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