Article
Metabolic induction and early responses of mouse blastocyst developmental programming following maternal low protein diet affecting life-long health.
PloS one - 1 Jan 2012
Eckert Judith J, Porter Richard, Watkins Adam J, Burt Elizabeth, Brooks Suzanne, Leese Henry J, Humpherson Peter G, Cameron Iain T, Fleming Tom P
Abstract excerpt
Previously, we have shown that a maternal low protein diet, fed exclusively during the preimplantation period of mouse development (Emb-LPD), is sufficient to induce by the blastocyst stage a compensatory growth phenotype in late gestation and postnatally, correlating with increased risk of adult onset cardiovascular disease and behavioural dysfunction. Here, we examine mechanisms of induction of maternal Emb-LPD...
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