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A multi-modal MRI analysis of brain structure and function in relation to OXT methylation in maltreated children and adolescents

17 Nov 2021

Abstract excerpt

Child maltreatment dysregulates the brain's oxytocinergic system, resulting in dysfunctional attachment patterns. However, how the oxytocinergic system in children who are maltreated (CM) is epigenetically affected remains unknown. We assessed differences in salivary DNA methylation of the gene encoding oxytocin (OXT) between CM (n = 24) and non-CM (n = 31), alongside its impact on brain structures and functions...

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PMID: 34789725
DOI: 10.1038/s41398-021-01714-y

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