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Regulation of blood‐testis barrier assembly in vivo by germ cells

28 Nov 2017

Abstract excerpt

The assembly of the blood‐testis barrier (BTB) during postnatal development is crucial to support meiosis. However, the role of germ cells in BTB assembly remains unclear. Herein, Kit W /Kit Wv mice were used as a study model. These mice were infertile, failing to establish a functional BTB to support meiosis due to c‐Kit mutation. Transplantation of undifferentiated spermatogonia derived from normal mice into...

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PMID: 29183964
DOI: 10.1096/fj.201700681r

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