In search of suitable in vitro models to study germ cell movement across the blood-testis barrier

Abstract excerpt

The movement of preleptotene/leptotene spermatocytes across the blood-testis barrier, also known as the Sertoli cell barrier, during stages VIII to XI of the seminiferous epithelial cycle is one of the most important cellular events taking place in the mammalian testis. Without the passage of spermatocytes, spermatogenesis would be halted, resulting in transient or permanent sterility. Unfortunately, we have very...

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