Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib.

DNA repair - 1 Jan 2018

Gravells Polly, Neale James, Grant Emma, Nathubhai Amit, Smith Kate M, James Dominic I, Bryant Helen E

Abstract excerpt

Upon DNA binding the poly(ADP-ribose) polymerase family of enzymes (PARPs) add multiple ADP-ribose subunits to themselves and other acceptor proteins. Inhibitors of PARPs have become an exciting and real prospect for monotherapy and as sensitizers to ionising radiation (IR). The action of PARPs are reversed by poly(ADP-ribose) glycohydrolase (PARG). Until recently studies of PARG have been limited by the lack of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Breaks, Double-Stranded
Share to Micronuclei, Chromosome-Defective

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phthalazines

Share to Poly(ADP-ribose) Polymerase Inhibitors

Share to Poly(ADP-ribose) Polymerases

Share to Rad51 Recombinase

Share to Radiation, Ionizing

Share to Radiation Tolerance

Source

Open in PubMed Open full text

Identifiers

PMID: 29179156
DOI: 10.1016/j.dnarep.2017.11.004
PMCID: PMC5765821

Genes

PARG
PARP1
PRKDC
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib.PMID 29179156Read ↗

PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkersSemantic proximity Read ↗

Review of Poly (ADP-ribose) Polymerase (PARP) Mechanisms of Action and Rationale for Targeting in Cancer and Other DiseasesSemantic proximity Read ↗

PARG inhibitor sensitivity correlates with accumulation of single-stranded DNA gaps in preclinical models of ovarian cancerSemantic proximity Read ↗

Poly(ADP‐ribose) and carcinogenesisSemantic proximity Read ↗

DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase InhibitorsSemantic proximity Read ↗

Poly(ADP-ribosylation) and genomic stabilitySemantic proximity Read ↗

PARP (Poly ADP‐ribose Polymerase) Family in Health and DiseaseSemantic proximity Read ↗

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancerSemantic proximity Read ↗

DNA Repair Enzyme Poly(ADP-Ribose) Polymerase 1/2 (PARP1/2)-Targeted Nuclear Imaging and RadiotherapySemantic proximity Read ↗

PolyADP‐ribosylation and cancerSemantic proximity Read ↗

Research Advances in the Role of the Poly ADP Ribose Polymerase Family in CancerSemantic proximity Read ↗

Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.