Article
A putative causal relationship between genetically determined female body shape and posttraumatic stress disorder.
Genome medicine - 27 Nov 2017
Polimanti Renato, Amstadter Ananda B, Stein Murray B, Almli Lynn M, Baker Dewleen G, Bierut Laura J, Bradley Bekh, Farrer Lindsay A, Johnson Eric O, King Anthony, Kranzler Henry R, Maihofer Adam X, Rice John P, Roberts Andrea L, Saccone Nancy L, Zhao Hongyu, Liberzon Israel, Ressler Kerry J, Nievergelt Caroline M, Koenen Karestan C, Gelernter Joel
Abstract excerpt
BACKGROUND: The nature and underlying mechanisms of the observed increased vulnerability to posttraumatic stress disorder (PTSD) in women are unclear. METHODS: We investigated the genetic overlap of PTSD with anthropometric traits and reproductive behaviors and functions in women. The analysis was conducted using female-specific summary statistics from large genome-wide association studies (GWAS) and a cohort of...
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