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Article

Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes.

European journal of psychotraumatology - 1 Dec 2025

Cusack Shannon E, Wright Anna W, Barr Peter B, Notari Emily, Bountress Kaitlin E, Amstadter Ananda B

Abstract excerpt

Objective: Posttraumatic stress disorder (PTSD) and life satisfaction phenotypes are inversely related on a phenotypic level. Given these established relations, researchers have begun to examine possible shared genetic contributions to these outcomes, though the existing genetic literature is sparse and examines these relations via univariate methods. We sought to examine the genetic architecture of PTSD and six...

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PMID: 39937039
DOI: 10.1080/20008066.2025.2463187
PMCID: PMC11823395

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