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Article

Hepatic Parenchymal Injury in Crigler-Najjar Type I.

Journal of pediatric gastroenterology and nutrition - 1 Apr 2018

Mitchell Ellen, Ranganathan Sarangarajan, McKiernan Patrick, Squires Robert H, Strauss Kevin, Soltys Kyle, Mazariegos George, Squires James E

Abstract excerpt

BACKGROUND: Crigler-Najjar syndrome type I (CNI) arises from biallelic variants of UGT1A1 that abrogate uridine diphosphate glucuronosyltransferase (UGT1A1) activity resulting in unconjugated hyperbilirubinemia. Historically, liver parenchyma in CNI was considered structurally and histologically normal. Recent review of CNI liver explants revealed fibrosis. Our aim was to investigate the association between...

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Identifiers

PMID: 29176474
DOI: 10.1097/MPG.0000000000001843

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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