Article
Differences in UGT1A1 gene mutations and pathological liver changes between Chinese patients with Gilbert syndrome and Crigler-Najjar syndrome type II.
Medicine - 1 Nov 2017
Sun Lei, Li Man, Zhang Liang, Teng Xiaoying, Chen Xiangmei, Zhou Xingang, Ma Zhiyuan, Qi Liming, Wang Peng
Abstract excerpt
Diagnosis of Crigler-Najjar syndrome type II (CNS-II) and Gilbert syndrome (GS) based on the serum bilirubin concentration is difficult, because this parameter can fluctuate under certain conditions. The aim of this study was to explore differences in UGT1A1 gene mutations, which cause both CNS and GS, and pathological changes between CNS-II and GS.Ninety-five Chinese patients with hereditary unconjugated...
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