Article
HashClone: a new tool to quantify the minimal residual disease in B-cell lymphoma from deep sequencing data.
BMC bioinformatics - 23 Nov 2017
Beccuti Marco, Genuardi Elisa, Romano Greta, Monitillo Luigia, Barbero Daniela, Boccadoro Mario, Ladetto Marco, Calogero Raffaele, Ferrero Simone, Cordero Francesca
Abstract excerpt
BACKGROUND: Mantle Cell Lymphoma (MCL) is a B cell aggressive neoplasia accounting for about the 6% of all lymphomas. The most common molecular marker of clonality in MCL, as in other B lymphoproliferative disorders, is the ImmunoGlobulin Heavy chain (IGH) rearrangement, occurring in B-lymphocytes. The patient-specific IGH rearrangement is extensively used to monitor the Minimal Residual Disease (MRD) after...
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