Article
Genomewide association study of HLA alloimmunization in previously pregnant blood donors.
Transfusion - 1 Feb 2018
Seielstad Mark, Page Grier P, Gaddis Nathan, Lanteri Marion, Lee Tzong-Hae, Kakaiya Ram, Barcellos Lisa F, Criswell Lindsey A, Triulzi Darrell, Norris Philip J, Busch Michael P
Abstract excerpt
BACKGROUND: Alloimmunization through blood transfusion, transplantation, or circulating fetal cells during pregnancy is a significant concern. Some exposed individuals make alloantibodies while others do not, implying variation in genetic risk factors. STUDY DESIGN AND METHODS: We conducted a genomewide association study (GWAS) of 9,427,497 single-nucleotide polymorphisms (SNPs) to identify genetic variants for...
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