MicroRNA-4443 Causes CD4+ T Cells Dysfunction by Targeting TNFR-Associated Factor 4 in Graves’ Disease

Abstract excerpt

Context: Aberrant CD4+ T cell function plays a critical role in the process of Graves' disease (GD). MicroRNAs (miRNAs) are important regulators of T cell activation, proliferation and cytokine production. However, the contribution of miRNAs to CD4+T cell dysfunction in GD remains unclear. Objective: To investigate how certain miRNA causes aberrant CD4+ T cell function in GD patients. Methods: We compared the...

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