Article
Whole Exome Sequencing reveals new candidate genes in host genomic susceptibility to Respiratory Syncytial Virus Disease.
Scientific reports - 21 Nov 2017
Salas Antonio, Pardo-Seco Jacobo, Cebey-López Miriam, Gómez-Carballa Alberto, Obando-Pacheco Pablo, Rivero-Calle Irene, Currás-Tuala María-José, Amigo Jorge, Gómez-Rial José, Martinón-Torres Federico
Abstract excerpt
Respiratory syncytial virus (RSV) is an important cause of serious lower respiratory tract disease in infants. Several studies have shown evidence pointing to the genome of the host as an important factor determining susceptibility to respiratory disease caused by RSV. We sequenced the complete exomes of 54 patients infected by RSV that needed hospitalization due to development of severe bronchiolitis. The...
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