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Article

Discovery of Variants Underlying Host Susceptibility to Virus Infection Using Whole-Exome Sequencing.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Leiva-Torres Gabriel A, Nebesio Nestor, Vidal Silvia M

Abstract excerpt

The clinical course of any viral infection greatly differs in individuals. This variation results from various viral, host, and environmental factors. The identification of host genetic factors influencing inter-individual variation in susceptibility to several pathogenic viruses has tremendously increased our understanding of the mechanisms and pathways required for immunity. Next-generation sequencing of whole...

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PMID: 28808973
DOI: 10.1007/978-1-4939-7237-1_14
PMCID: PMC7120756

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