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Article

Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant.

Scientific reports - 17 Nov 2017

Chen Haiqi, Gao Ying, Mruk Dolores D, Xiao Xiang, John Constance M, Turek Paul J, Lui Wing-Yee, Lee Will M, Silvestrini Bruno, Cheng C Yan

Abstract excerpt

PFOS induces Sertoli cell injury using testicular cells isolated from rodent testes, but it remains unknown if PFOS has similar effects in humans. Herein, we maintained human Sertoli cells in a mitotically active state in vitro, thus enabling transfection experiments that altered gene expression to explore the molecular mechanism(s) underlying toxicant-induced cell injury. Human Sertoli cells obtained from men at...

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Identifiers

PMID: 29150642
DOI: 10.1038/s41598-017-15671-4
PMCID: PMC5693862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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