Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study.

Endocrinology - 1 Jan 2014

Wan Hin-Ting, Mruk Dolores D, Wong Chris K C, Cheng C Yan

Abstract excerpt

Environmental toxicants such as perfluorooctanesulfonate (PFOS) have been implicated in male reproductive dysfunction, including reduced sperm count and semen quality, in humans. However, the underlying mechanism(s) remains unknown. Herein PFOS at 10-20 μM (∼5-10 μg/mL) was found to be more potent than bisphenol A (100 μM) in perturbing the blood-testis barrier (BTB) function by disrupting the Sertoli cell tight...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzhydryl Compounds
Share to Connexin 43

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Gap Junctions

Share to Permeability

Share to Phenols

Share to Sertoli Cells

Share to Tight Junctions

Source

Open in PubMed Open full text

Identifiers

PMID: 24169556
DOI: 10.1210/en.2013-1657
PMCID: PMC3868803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study.PMID 24169556Read ↗

Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant.Semantic proximity Read ↗

Cell-Cell Interaction-Mediated Signaling in the Testis Induces Reproductive Dysfunction—Lesson from the Toxicant/Pharmaceutical ModelsSemantic proximity Read ↗

PFOS Disrupts Membrane Signaling and Epithelial Integrity in Fallopian Tube CellsSemantic proximity Read ↗

Sertoli cells are the target of environmental toxicants in the testis – a mechanistic and therapeutic insightSemantic proximity Read ↗

Microinjection-based Single-Cell Toxicological Assessment Reveals How Physiological Levels of PFOS Impair Oocyte Maturation and Developmental CompetenceSemantic proximity Read ↗

Mechanistic Insights into PFOS-Mediated Sertoli Cell InjurySemantic proximity Read ↗

Perfluorooctane sulfonate exposure induces preeclampsia-like syndromes by damaging trophoblast mitochondria in pregnant miceSemantic proximity Read ↗

Developmental exposure to perfluorooctanoic sulfonate（PFOS） impairs the endometrial receptivitySemantic proximity Read ↗

Testicular histopathology associated with disruption of the Sertoli cell cytoskeletonSemantic proximity Read ↗

Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genesSemantic proximity Read ↗

Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunctionSemantic proximity Read ↗

PFOS induces proliferation, cell-cycle progression, and malignant phenotype in human breast epithelial cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.