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The role of lipid metabolism and peroxisome proliferator activation in mediating pro-cancer phenotypes of poly- and perfluoroalkyl substances in testicular cancer.

Environmental toxicology and pharmacology - 1 Dec 2025

Boyd Raya I, Shokry Doha, Rennels Brayden C, Adam Younan, Powell Christine, Johnson Samantha, Spinella Michael J, Singh Ratnakar

Abstract excerpt

Poly- and perfluoroalkyl substances (PFAS) are of human health concern as epidemiological studies show significant associations with testicular germ cell tumors (TGCTs). Here, the effects of perfluorooctanesulfonic acid (PFOS), lithium bis(trifluoromethylsulfonyl)imide (HQ-115), and hexafluoropropylene oxide dimer acid (GenX) on TGCT cells were investigated. Concentrations (10 nM to 1 µM) modelled PFAS doses in...

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Cell Line, Tumor
Lipid Metabolism
Neoplasms, Germ Cell and Embryonal
Peroxisome Proliferator-Activated Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Testicular Neoplasms

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Identifiers

PMID: 41237835
DOI: 10.1016/j.etap.2025.104866
PMCID: PMC13371115

Genes

PFAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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