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Article

The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance.

G3 (Bethesda, Md.) - 4 Jan 2018

Dos Reis Thaila Fernanda, Silva Lilian Pereira, de Castro Patrícia Alves, Almeida de Lima Pollyne Borborema, do Carmo Rafaela Andrade, Marini Marjorie Mendes, da Silveira José Franco, Ferreira Beatriz Henriques, Rodrigues Fernando, Malavazi Iran, Goldman Gustavo H

Abstract excerpt

Genetic stability is extremely important for the survival of every living organism, and a very complex set of genes has evolved to cope with DNA repair upon DNA damage. Here, we investigated the Aspergillus fumigatus AtmA (Ataxia-telangiectasia mutated, ATM) and AtrA kinases, and how they impact virulence and the evolution of azole resistance. We demonstrated that A. fumigatus atmA and atrA null mutants are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29150592
DOI: 10.1534/g3.117.300265
PMCID: PMC5765354

Genes

ATM

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