Article
Genetic risk factors for perception of symptoms in GERD: an observational cohort study.
Alimentary pharmacology & therapeutics - 1 Jan 2018
Patel A, Hasak S, Nix B D, Sayuk G S, Newberry R D, Gyawali C P
Abstract excerpt
BACKGROUND: Genetic polymorphisms in G-protein beta-3 subunit (GNβ3) and beta-2 adrenergic receptor (ADRB2) are associated with pain and gut hypersensitivity, which can overlap with gastroesophageal reflux disease (GERD). AIM: To evaluate relationships between single nucleotide polymorphisms (SNPs) within GNβ3 and ADRB2 systems, and reflux symptom burden, GERD phenotypes from ambulatory reflux monitoring, and...
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