Article
SNP association study in PMS2-associated Lynch syndrome.
Familial cancer - 1 Oct 2018
Ten Broeke Sanne W, Elsayed Fadwa A, Pagan Lisa, Olderode-Berends Maran J W, Garcia Encarna Gomez, Gille Hans J P, van Hest Liselot P, Letteboer Tom G W, van der Kolk Lizet E, Mensenkamp Arjen R, van Os Theo A, Spruijt Liesbeth, Redeker Bert J W, Suerink Manon, Vos Yvonne J, Wagner Anja, Wijnen Juul T, Steyerberg E W, Tops Carli M J, van Wezel Tom, Nielsen Maartje
Abstract excerpt
Lynch syndrome (LS) patients are at high risk of developing colorectal cancer (CRC). Phenotypic variability might in part be explained by common susceptibility loci identified in Genome Wide Association Studies (GWAS). Previous studies focused mostly on MLH1, MSH2 and MSH6 carriers, with conflicting results. We aimed to determine the role of GWAS SNPs in PMS2 mutation carriers. A cohort study was performed in 507...
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