Article
Leveraging genome characteristics to improve gene discovery for putamen subcortical brain structure.
Scientific reports - 16 Nov 2017
Chen Chi-Hua, Wang Yunpeng, Lo Min-Tzu, Schork Andrew, Fan Chun-Chieh, Holland Dominic, Kauppi Karolina, Smeland Olav B, Djurovic Srdjan, Sanyal Nilotpal, Hibar Derrek P, Thompson Paul M, Thompson Wesley K, Andreassen Ole A, Dale Anders M
Abstract excerpt
Discovering genetic variants associated with human brain structures is an on-going effort. The ENIGMA consortium conducted genome-wide association studies (GWAS) with standard multi-study analytical methodology and identified several significant single nucleotide polymorphisms (SNPs). Here we employ a novel analytical approach that incorporates functional genome annotations (e.g., exon or 5'UTR), total linkage...
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