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Article

An unexpected protein interaction promotes drug resistance in leukemia

10 Nov 2017

Abstract excerpt

The overall survival of patients with acute myeloid leukemia (AML) is poor and identification of new disease-related therapeutic targets remains a major goal for this disease. Here we show that expression of MPP1, a PDZ-domain-containing protein, highly correlated with ABCC4 in AML, is associated with worse overall survival in AML. Murine hematopoietic progenitor cells overexpressing MPP1 acquired the ability to...

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PMID: 29146910
DOI: 10.1038/s41467-017-01678-y

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