Article
Respiratory stress in mitochondrial electron transport chain complex mutants of Candida albicans activates Snf1 kinase response.
Fungal genetics and biology : FG & B - 1 Feb 2018
Zhang Pengyi, Li Hongbin, Cheng Jie, Sun April Y, Wang Liqing, Mirchevska Gordana, Calderone Richard, Li Dongmei
Abstract excerpt
We have previously established that mitochondrial Complex I (CI) mutants of Candida albicans display reduced oxygen consumption, decreased ATP production, and increased reactive oxidant species (ROS) during cell growth. Using the Seahorse XF96 analyzer, the energetic phenotypes of Electron Transport Chain (ETC) complex mutants are further characterized in the current study. The underlying regulation of energetic...
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