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Article

Immature CML cells implement a BMP autocrine loop to escape TKI treatment

14 Nov 2017

Abstract excerpt

cells. We demonstrated persistent and increasing BMP4 production by patients' mesenchymal cells with resistance. Patient follow-up revealed an increase of BMPR1b expression and in BMP4 expression in LSC from TKI-resistant patients in comparison with diagnosis, while remaining unchanged in sensitive patients. Both leukemic and nonleukemic cells exhibit higher BMP4 levels in the bone marrow of TKI-resistant...

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PMID: 29138221
DOI: 10.1182/blood-2017-08-801019

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