Effects of pH in the in vitro chromosomal aberration test.

doi:10.1016/0165-7992(89)90033-x

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Article

Effects of pH in the in vitro chromosomal aberration test.

Mutation research - 1 Jan 2000

Morita T, Watanabe Y, Takeda K, Okumura K

Abstract excerpt

The relation between the pH of the medium and clastogenic activity was studied in Chinese hamster ovary (CHO) K1 cells in vitro. The pH was adjusted with NaOH, KOH, HCl or H2SO4. No clastogenic activity was observed over the initial pH range of 7.3-10.9 without S9 mix, but a few chromosomal aberr...

Topics

Animals
Cell Line
Chromosome Aberrations
Hydrogen-Ion Concentration
Microsomes, Liver
Mutagenicity Tests
Mutation
Rats

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