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EFEMP2 indicates assembly of M0 macrophage and more malignant phenotypes of glioma.

Aging - 12 May 2020

Huang Lijie, Wang Zheng, Chang Yuanhao, Wang Kuanyu, Kang Xun, Huang Ruoyu, Zhang Ying, Chen Jing, Zeng Fan, Wu Fan, Zhao Zheng, Li Guanzhang, Huang Hua, Jiang Tao, Hu Huimin

Abstract excerpt

Immune response mediated by macrophages is critical in tumor progression and implicates new targets in potential efficient immunotherapies. Tumor associated macrophages (TAM) are divided into either polarized M1 or M2 phenotype depending on different regulators of polarization and pro- or anti-oncogenic roles they play. Glioma-infiltrated TAMs have been newly reported contrary to the current polarization dogma....

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Identifiers

PMID: 32396873
DOI: 10.18632/aging.103147
PMCID: PMC7244085

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