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Article

Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice.

Journal of vascular research - 1 Jan 2017

Ivic Ivan, Solymar Margit, Fulop Balazs D, Hashimoto Hitoshi, Toth Gabor, Tamas Andrea, Juhasz Tamas, Koller Akos, Reglodi Dora

Abstract excerpt

Pituitary adenylate cyclase-activating peptide (PACAP; 1-38 and 1-27) and vasoactive intestinal peptide (VIP) are related neuropeptides of the secretin/glucagon family. Overlapping signaling through G-protein-coupled receptors mediates their vasomotor activity. We previously showed that PACAP deficiency (PACAP-KO) shifts the mechanisms of vascular response and maintains arterial relaxation through the VIP backup...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 29131060
DOI: 10.1159/000481781

Genes

VIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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