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Recurrent ubiquitin B silencing in gynecological cancers establishes dependence on ubiquitin C

12 Nov 2017

Abstract excerpt

Transcriptional repression of ubiquitin B (UBB) is a cancer-subtype-specific alteration that occurs in a substantial population of patients with cancers of the female reproductive tract. UBB is 1 of 2 genes encoding for ubiquitin as a polyprotein consisting of multiple copies of ubiquitin monomers. Silencing of UBB reduces cellular UBB levels and results in an exquisite dependence on ubiquitin C (UBC), the second...

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PMID: 29130934
DOI: 10.1172/jci92914

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