Article
Lack of chronic neuroinflammation in the absence of focal hemorrhage in a rat model of low-energy blast-induced TBI.
Acta neuropathologica communications - 10 Nov 2017
Gama Sosa Miguel A, De Gasperi Rita, Perez Garcia Georgina S, Sosa Heidi, Searcy Courtney, Vargas Danielle, Janssen Pierce L, Perez Gissel M, Tschiffely Anna E, Janssen William G, McCarron Richard M, Hof Patrick R, Haghighi Fatemeh G, Ahlers Stephen T, Elder Gregory A
Abstract excerpt
Blast-related traumatic brain injury (TBI) has been a common cause of injury in the recent conflicts in Iraq and Afghanistan. Blast waves can damage blood vessels, neurons, and glial cells within the brain. Acutely, depending on the blast energy, blast wave duration, and number of exposures, blast waves disrupt the blood-brain barrier, triggering microglial activation and neuroinflammation. Recently, there has...
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