Article
Copy Number Variant in the Region of Adenosine Kinase (ADK) and Its Possible Contribution to Schizophrenia Susceptibility.
The international journal of neuropsychopharmacology - 1 May 2018
Kimura Hiroki, Kushima Itaru, Yohimi Akira, Aleksic Branko, Ozaki Norio
Abstract excerpt
Background: Adenosine kinase (ADK) is supposed to be a schizophrenia susceptibility gene based on the findings that ADK is an enzyme that catalyzes transfer of the gamma-phosphate from ATP to adenosine, which interacts with dopamine and glutamate neurotransmitters. However, no reports of schizophrenia cases with loss of function variants in the ADK region have been published. In our previous study investigating...
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