Article
Retinoblastoma for Pediatric Ophthalmologists.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) - 1 Jan 2000
AlAli Alaa, Kletke Stephanie, Gallie Brenda, Lam Wai-Ching
Abstract excerpt
Retinoblastoma can present in 1 or both eyes and is the most common intraocular malignancy in childhood. It is typically initiated by biallelic mutation of the RB1 tumor suppressor gene, leading to malignant transformation of primitive retinal cells. The most common presentation is leukocoria, followed by strabismus. Heritable retinoblastoma accounts for 45% of all cases, with 80% being bilateral. Treatment and...
Topics
- Child
- DNA, Neoplasm
- Genes, Retinoblastoma
- Genetic Testing
- Humans
- Mutation
- Ophthalmologists
- Retinal Neoplasms
- Retinoblastoma