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Article

Lysophosphatidate Signaling: The Tumor Microenvironment's New Nemesis.

Trends in cancer - 1 Nov 2017

Benesch Matthew G K, Yang Zelei, Tang Xiaoyun, Meng Guanmin, Brindley David N

Abstract excerpt

Lysophosphatidate (LPA) is emerging as a potent mediator of cancer progression in the tumor microenvironment. Strategies for targeting LPA signaling have recently entered clinical trials for fibrosis. These therapies have potential to improve the efficacies of existing chemotherapies and radiotherapy by attenuating chronic inflammation, irrespective of diverse mutations within cancer cells.

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Source

Identifiers

PMID: 29120750
DOI: 10.1016/j.trecan.2017.09.004

Genes

LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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