Article
Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling.
International journal of cardiology - 15 Jan 2018
Wu Bing, Zhang Lei, Zhu Yun-He, Zhang You-En, Zheng Fei, Yang Jian-Ye, Guo Ling-Yun, Li Xing-Yuan, Wang Lu, Tang Jun-Ming, Chen Shi-You, Wang Jia-Ning
Abstract excerpt
AIMS: To investigate the role of mesoderm/mesenchyme homeobox gene l (Meox1) in vascular smooth muscle cells (SMCs) phenotypic modulation during vascular remodeling. METHODS AND RESULTS: By using immunostaining, Western blot, and histological analyses, we found that Meox1 was up-regulated in PDGF-BB-treated SMCs in vitro and balloon injury-induced arterial SMCs in vivo. Meox1 knockdown by shRNA restored the...
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