Article
The induction of yes-associated protein expression after arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2012
Wang Xiaobo, Hu Guoqing, Gao Xiangwei, Wang Yong, Zhang Wei, Harmon Erin Yund, Zhi Xu, Xu Zhengping, Lennartz Michelle R, Barroso Margarida, Trebak Mohamed, Chen Ceshi, Zhou Jiliang
Abstract excerpt
OBJECTIVE: Abnormal proliferation and migration of vascular smooth muscle cells (SMCs) are the key events in the progression of neointima formation in response to vascular injury. The goal of this study is to investigate the functional role of a potent oncogene yes-associated protein (YAP) in SM phenotypic modulation in vitro and in vivo. METHODS AND RESULTS: In vitro cell culture and in vivo in both mouse and...
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