Article
The impacts of nineteen mutations on the enzymatic activity of USP26.
Gene - 30 Jan 2018
Liu Ying-Li, Zheng Jie, Mi Ying-Jun, Zhao Jing, Tian Qing-Bao
Abstract excerpt
OBJECTIVE: The association between mutations in the USP26 gene and male infertility has been studied intensively. However, the biological function of the mutant proteins remains to be elucidated. To confirm the effects of the reported mutations, we analyse the enzyme activity of USP26 between the wild-type and the variants from a molecular perspective. METHODS: Using pGEX-USP26 as a template, site-directed...
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